Nitrosoamines have been detected in various products such as pharmaceuticals, pharmaceuticals, cosmetics, rubber and plastic products.
It is a carcinogenic substance, and the Ministry of Health, Labor and Welfare has notified that the risk of contamination with nitrosamine in pharmaceutical products should be voluntarily inspected by April 30, 2023. An example of analysis performed using Inert Sustain PFP with reference to the FDA (American Food and Drug Administration) literature is posted on Inert Search LB691 (https://www.gls.co.jp/technique/app/detail..php? data_number = LB691).
This time, we examined the analysis conditions for rapid measurement of 8 components of nitrosoamines with LC-MS / MS, and by using InertSustain AQ-C18 HP, it became possible to analyze in 6 minutes. to introduce. In addition, we will also introduce an example of analysis by HPLC / DAD.